Table 1.
Baseline characteristics of 41 patients with newly diagnosed POEMS syndrome.
| Baseline | N (%) | Median (range) |
|---|---|---|
| Male | 28 (68) | NA |
| Age at diagnosis, years | NA | 49 (21–70) |
| Time from symptoms to diagnose, months | NA | 7 (1-84) |
| Polyneuropathy | 41 (100) | NA |
| ONLS score | ||
| Upper limb | NA | 1 (0–4) |
| Lower limb | NA | 2 (1–7) |
| Overall | NA | 4 (1–10) |
| Organomegaly | 41 (100) | NA |
| Lymphadenopathy | 38 (93) | NA |
| Splenomegaly | 22 (54) | NA |
| Hepatomegaly | 12 (29) | NA |
| Endocrinopathy | 41 (100.0) | NA |
| Diabetes mellitus | 6 (15) | NA |
| Hypothyroidism | 17 (42) | NA |
| Gynecomastia (Male) | 21/28 (75) | NA |
| Increased ACTH | 28/39 (72) | NA |
| M-protein | 41 (100.0) | NA |
| IgAλ | 25 (61) | NA |
| IgAλ + IgGκ | 1 (2) | NA |
| IgAλ + IgMλ | 1 (2) | NA |
| IgGλ | 13 (32) | NA |
| λ | 1(2) | NA |
| Skin change | 41 (100.0) | NA |
| Hyperpigmentation | 38 (93) | NA |
| Hemangiomas | 33 (81) | NA |
| White nails | 25 (61) | NA |
| Hypertrichosis | 15 (37) | NA |
| Acrocyanosis | 6 (15) | NA |
| Dry skin and ichthyosis-like lesions | 9 (22) | NA |
| Bone lesion | 31 (76) | NA |
| Extravascular overload | 40 (98) | NA |
| Edema | 39 (95) | NA |
| Ascites | 17 (42) | NA |
| Pleural effusion | 21 (51) | NA |
| Periscardial effusion | 28 (68) | NA |
| Serum VEGF, pg/ml | 40 (98) | 5155 (534–14328) |
| Pulmonary hypertension, % | 3 (7) | 54 (51–93) |
| Papilledema | 23 (56) | NA |
| Erythrocytosis | 8 (20) | 138 (94–182) |
| Thrombocytosis | 18 (44) | 332 (89–628) |
NA, not available; ONLS, overall neuropathy limitation scale; ACTH, adrenocorticotropic hormone; VEGF, vascular endothelial growth factor.