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. 2021 May 6;15:646537. doi: 10.3389/fnins.2021.646537

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Copyright © 2021 Tan, Qiu, Zhang, Yang, Yin, Li, Liu, Li and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tetramethylpyrazine (TMP) administration alleviates depression and anxiety in rats caused by BCCAO/CRS. (A) Representational traces showing rats moving in the elevated plus maze (EPM) test. (B) Bargraph indicating the percentage of time that rats were moving/staying in the open arms. (C) Barchart demonstrating times that rats entered the open arms during EPM test. (D) Quantitation of the stretching number in rats during EPM test. (E) Typical route representing rats moving in the open field. (F) Summarized data demonstrating the total time of rats in the center during OFT. (G) Quantitative data summarizing the total time of rats in the corner during OFT. (H) Quantitative analysis of rats moving distance during the OFT. **P < 0.01 vs. Sham. ^#P < 0.05, ^##P < 0.01, ^nsP > 0.05 vs. BCCAO/CRS. Data are presented as mean ± SE. n = 10 in each group.