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. 2021 May 6;12:686874. doi: 10.3389/fphar.2021.686874

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Copyright © 2021 Chen, Ni, Yuan, Xu, Bahri, Sun, Wu and Ou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Cell growth was evaluated in KIT-independent GIST cell line (GIST62) after treatment with Imatinib (1 μM), PP1 (1 μM), AG490 (10 μM), Δ609 (1 μM), LY294002 (50 μM), U0126 (10 μM), Everolimus (1 μM), Nutlin-3 (5 μM), Bortezomib (100 nM), and 17-AAG (0.5 μM) for 72 h. (B) Immunoblotting evaluated expression of cyclin D1, p53, and p21 in GIST62 cells after treatment with the bortezomib for 72 h. Actin stain is a loading control. Linear capture quantitation of immunoblotting chemiluminescence signals, using an ImageQuant LAS4000. Intensity values are standardized to the DMSO control.