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. 2021 May 6;12:686874. doi: 10.3389/fphar.2021.686874

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Copyright © 2021 Chen, Ni, Yuan, Xu, Bahri, Sun, Wu and Ou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro wounding assays (A) and transwell migration assays (B) show that bortezomib treatment effectively inhibits migration and invasion of KIT-independent GIST cell lines (GIST48B, GIST54, and GIST226). Scale bars: 100 μm. Wound healing and transwell experiments were performed in triplicate. (C) Quantitation (A₅₇₀) of KIT-independent GIST cell (GIST48B and GIST54) invasiveness after treatment bortezomib for 72 h. Statistically significant differences between untreated control and bortezomib treatments are presented as **p < 0.01, ****p < 0.0001.