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Screening of small molecular inhibitors in KIT-independent GIST62.
| Targets | Inhibitors | Concentrations (μM) |
|---|---|---|
| KIT | Imatinib | 1.0 |
| SRC | PP1 | 5.0 |
| JAK | AG490 | 10 |
| PLCγ | △609 | 1.0 |
| PI3K | LY294002 | 50 |
| MEK | U0126 | 1.0 |
| MTOR | Everolimus | 1.0 |
| MDM2 | Nutlin-3 | 5.0 |
| 26S Proteasome | Bortezomib | 0.1 |
| HSP90 | 17-AAG | 0.5 |
