(A) Schematic illustration of the PRDCuS@AG for deep tumor combination chemophototherapy. (B) 4T1 tumor section images after intravenous (i.v.) injection of PD@AG and PRDCuS@ AG (2 mg/mL, 100 μL) for 12 h. The corresponding fluorescence intensity of DAPI and DOX across along the lines in the 4T1 tumor section images are also shown. The arrow represents the direction of the lines. Blue (DAPI), nucleus; green (CD31), blood vessel; red, DOX. The concentration of DOX in PD@AG and PRDCuS@AG groups is equivalent. Scale bar is 100 μm. Reproduced with permission [99], Copyright 2020, Wiley-VCH.