Table 5.
Diagnostic validity of laboratory parameters
| AUCa | AUC 95% ICb | LR + c | LR-d | YIe | Sensitivity (%) | Specificity (%) | ||
|---|---|---|---|---|---|---|---|---|
| IL6f (pg/mL) | ||||||||
| Best cut-off | 69.08 | 0.70 | 0.64–0.76 | 0.31 | 51.24 | 79.86 | ||
| Best cut-off for LR+ | 175.1 | 5.2 | 28.10 | 94.60 | ||||
| Best cut-off for LR- | 5.56 | 0.19 | 97.52 | 12.59 | ||||
| CRPg (mg/L) | ||||||||
| Best cut-off | 97.3 | 0.67 | 0.65–0.73 | 0.28 | 62.18 | 66.05 | ||
| Best cut-off for LR+ | 291.85 | 5.16 | 14.29 | 97.23 | ||||
| Best cut-off for LR- | 7 | 0.21 | 97.90 | 11.62 | ||||
| Ferritin (ng/mL) | ||||||||
| Best cut-off | 632.5 | 0.67 | 0.62–0.73 | 0.29 | 72.66 | 56.79 | ||
| Best cut-off for LR+ | 2688.5 | 5.51 | 12.23 | 87.77 | ||||
| Best cut-off for LR- | 162 | 0.17 | 97.12 | 16.62 | ||||
| LDHh (U/L) | ||||||||
| Best cut-off | 328.5 | 0.71 | 0.66–0.75 | 0.36 | 65.58 | 70.62 | ||
| Best cut-off for LR+ | 574 | 5.34 | 17.21 | 96.78 | ||||
| Best cut-off for LR- | 177.5 | 0.3 | 88.37 | 30.99 | ||||
| D-dimer (ng/mL) | ||||||||
| Best cut-off | 1068 | 0.62 | 0.57–0.66 | 0.21 | 45.28 | 76.12 | ||
| Best cut-off for LR+ | 34,744 | 4.62 | 1.89 | 99.59 | ||||
| Best cut-off for LR- | None | na. | na. | |||||
| Leucocyte count (cells*103/μL) | ||||||||
| Best cut-off | 7.835 | 0.62 | 0.58–0.67 | 0.22 | 50.57 | 71.90 | ||
| Best cut-off for LR+ | 15.875 | 5.14 | 9.89 | 98.08 | ||||
| Best cut-off for LR- | None | na. | na. | |||||
| Neutrophil count (cells*103/μL) | ||||||||
| Best cut-off | 6.26 | 0.66 | 0.62–0.70 | 0.27 | 51.33 | 75.44 | ||
| Best cut-off for LR+ | 13.04 | 5.37 | 12.17 | 97.74 | ||||
| Best cut-off for LR- | None | na. | na. | |||||
| Lymphocyte count (cells*103/μL) | ||||||||
| Best cut-off | 0.725 | 0.61 | 0.57–0.65 | 0.18 | 39.92 | 77.66 | ||
| Best cut-off for LR+ | 0.365 | 5.34 | 10.27 | 98.08 | ||||
| Best cut-off for LR- | None | na. | na. | |||||
| CD3 + CD4+ count (cells/μL) | ||||||||
| Best cut-off | 535.5 | 0.70 | 0.61–0.80 | 0.41 | 90.32 | 50.51 | ||
| Best cut-off for LR+ | 95.74 | 4.79 | 9.68 | 97.98 | ||||
| Best cut-off for LR- | 660.6 | 0.16 | 93.55 | 39.39 | ||||
| CD4 + CD8+ count (cells/μL) | ||||||||
| Best cut-off | 162.83 | 0.63 | 0.52–0.75 | 0.22 | 58.06 | 63.64 | ||
| Best cut-off for LR+ | None | na. | na. | |||||
| Best cut-off for LR- | None | na. | na. | |||||
| CD19+ count (cells/μL) | ||||||||
| Best cut-off | na.i | 0.59 | 0.47–0.71 | na. | na. | na. | ||
| Best cut-off for LR+ | na. | na. | na. | |||||
| Best cut-off for LR- | na. | na. | na. | |||||
| Natural Killer count (cells/μL) | ||||||||
| Best cut-off | 147.5 | 0.65 | 0.54–0.77 | 0.28 | 75.00 | 53.26 | ||
| Best cut-off for LR+ | 43.29 | 5.11 | 16.67 | 96.74 | ||||
| Best cut-off for LR- | 229.38 | 0.18 | 95.83 | 22.83 | ||||
Abbreviations: AUCa Area under the curve, AUC 96% ICb 95% Confidence Intervale of the area under the curve, LRc Likelyhood ratio positive, LR-d Likelyhood ratio negative, YIe Youden Index, IL6f Interleukin 6, CRPg C-reactive protein, LDHh Lactate dehydrogenase, na.i Non aplicable