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. 2021 Apr 19;3(2):fcab082. doi: 10.1093/braincomms/fcab082

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Correlations for (A) site cg05575921 (dark blue) and blood-derived lifestyle trait predictor scores for (B) smoking, (C) HDL, (D) alcohol and (E) BMI traits applied to the blood and brain (light blue). Relationships between brain DNAm and blood DNAm are shown for each brain region and measure. Each point represents one individual. Pearson correlation coefficients are annotated in each case. All individuals had both blood and brain samples available (n = 14), apart from one individual for which no BA35 hippocampal sample was available (n = 13). The solid blue line represents the linear regression slope; shaded areas represent 95% confidence intervals.