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. 2021 May 11;24(1):508. doi: 10.3892/mmr.2021.12147

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — LY-294002 promotes HepG2^R apoptosis induced by oxaliplatin. (A and D) LY-294002, oxaliplatin or LY-294002 combined with oxaliplatin for 24 h. Effect of LY-294002 on the apoptosis of liver cancer cells induced by oxaliplatin was determined with Annexin V FITC/PI staining. Magnification, ×400. (B and E) After 24 h treatment with LY-294002, oxaliplatin, or LY-294002 combined with oxaliplatin, the mitochondrial membrane potential was measured using JC-1 staining and flow cytometry. (C and F, G) After 24 h of treatment with LY-294002, oxaliplatin or LY-294002 combined with oxaliplatin, western blot analysis was used to determine the effect of LY-294002 on oxaliplatin-induced apoptosis. *P<0.05, **P<0.01 and ***P<0.001. OXA, oxaliplatin; p-, phosphorylated; ^R, resistant; c, cleaved.