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Examples of detected structural variants in cancer cell lines
(A) The chr8-chr12 translocation shows the integration of an Myc carrying ecDNA molecule onto chr12 in H460.
(B) A RACGAP1-AKAP6 fusion on CAKI-2.
(C) The BCR-ABL1 fusion on K562.
(D) Deletion of the genes ORC6 and MYLK3 with a partial inversion.
(E) A translocation that disrupts CDC25A and GRID1 but the direction is inconsistent with a fusion event.
(F) A “fold-back” inversion that duplicates and inverts GPC5 in K562.
