Table 1.
Baseline characteristics of study cohort
| Variable | Female | Male | Total |
|---|---|---|---|
| Total | 213,475 (45.8) | 253,001 (54.2) | 466,476 |
| Median age (IQR), years | 80.0 (72.0-86.0) | 74.0 (65.0-82.0) | 77 (68-84) |
| Age < 65 years | 25,578 (12.0) | 63,111 (24.9) | 88,689 (19.0) |
| Age 65-74 years | 41,617 (19.5) | 67,032 (26.5) | 108,649 (23.2) |
| Age 75-84 years | 78,291 (36.7) | 81,988 (32.4) | 160,279 (34.3) |
| Age ≥ 85 years | 67,989 (31.8) | 40,870 (16.2) | 108,859 (23.3) |
| CHADS2 | |||
| 0 | 26760 (12.5) | 50492 (20.0) | 77252 (16.6) |
| 1 | 63442 (29.7) | 79194 (31.3) | 142636 (30.6) |
| 2 | 66573 (31.2) | 69275 (27.4) | 135848 (29.1) |
| 3 | 36746 (17.2) | 36456 (14.4) | 73202 (15.7) |
| 4 | 15598 (7.3) | 13760 (5.4) | 29358 (6.3) |
| 5 | 3736 (1.8) | 3320 (1.3) | 7056 (1.5) |
| 6 | 620 (0.3) | 504 (0.2) | 1124 (0.2) |
| Median CHADS2 (IQR) | 2 (1-3) | 1 (1-2) | 2 (1-2) |
| CHA2DS2-VASc | |||
| 0 | 0 (0.0) | 24,456 (9.7) | 24,456 (5.2) |
| 1 | 11,422 (5.4) | 33,930 (13.4) | 45,352 (9.7) |
| 2 | 19,781 (9.3) | 59,773 (23.6) | 79,554 (17.1) |
| 3 | 53,085 (24.9) | 59,893 (23.7) | 112,978 (24.2) |
| 4 | 58,326 (27.3) | 43,245 (17.1) | 101,571 (21.8) |
| 5 | 40,185 (18.8) | 22,429 (8.9) | 62,614 (13.4) |
| 6 | 21,892 (10.3) | 7548 (3.0) | 29,440 (6.3) |
| 7 | 7144 (3.3) | 1414 (0.6) | 8558 (1.8) |
| 8 | 1351 (0.6) | 313 (0.1) | 1664 (0.4) |
| 9 | 289 (0.1) | 0 (0.0) | 289 (0.1) |
| Median CHA2DS2-VASc (IQR) | 4 (3-5) | 3 (2-4) | 3 (2-4) |
| Pre-existing conditions | |||
| Diabetes | 49,707 (23.3) | 69,894 (27.6) | 119,601 (25.6) |
| Hypertension | 97,384 (45.6) | 106,784 (42.2) | 204,168 (43.8) |
| Coronary artery disease | 31,880 (14.9) | 67,496 (26.7) | 99,376 (21.3) |
| Vascular disease | 46,247 (21.7) | 84,304 (33.3) | 130,551 (28.0) |
| Heart failure | 56,541 (26.5) | 62,288 (24.6) | 118,829 (25.5) |
| Stroke/TIA | 20,853 (9.8) | 19,976 (7.9) | 40,829 (8.8) |
| Stroke/embolism | 17,805 (8.3) | 17,092 (6.8) | 34,897 (7.5) |
Data are presented as n (%) except where otherwise noted. All comparisons according to sex were statistically significant (P < 0.0001).
CHADS2, Congestive Heart Failure, Hypertension, Age, Diabetes, Stroke/Transient Ischemic Attack; CHA2DS2-VASc, Congestive Heart Failure, Hypertension, Age (≥75 years), Diabetes, Stroke/Transient Ischemic Attack, Vascular Disease, Age (65-74 years), Sex (Female); IQR, interquartile range; TIA, transient ischemic attack.