Table 2.
One-year crude outcome incidence according to fiscal year
| Variable | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | Total | P∗ |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient n | 53,544 | 50,494 | 50,178 | 50,033 | 50,505 | 51,998 | 52,803 | 53,066 | 53,855 | 466,476 | |
| Stroke/embolism, n (%) | 1917 (3.6) | 1737 (3.4) | 1761 (3.5) | 1728 (3.5) | 1904 (3.8) | 1843 (3.5) | 1822 (3.5) | 1790 (3.4) | 1760 (3.3) | 16,262 (3.5) | 0.002 |
| Ischemic stroke, n (%) | 1498 (2.8) | 1341 (2.7) | 1357 (2.7) | 1329 (2.7) | 1468 (2.9) | 1403 (2.7) | 1405 (2.7) | 1389 (2.6) | 1359 (2.5) | 12,549 (2.7) | 0.016 |
| Hemorrhagic stroke, n (%) | 352 (0.7) | 311 (0.6) | 359 (0.7) | 320 (0.6) | 357 (0.7) | 358 (0.7) | 335 (0.6) | 341 (0.6) | 329 (0.6) | 3062 (0.7) | 0.32 |
| Major bleeding, n (%) | 923 (1.7) | 798 (1.6) | 880 (1.8) | 774 (1.5) | 820 (1.6) | 845 (1.6) | 856 (1.6) | 900 (1.7) | 865 (1.6) | 7661 (1.6) | 0.16 |
| Patient n† | 39,069 | 37,180 | 36,918 | 37,252 | 37,886 | 39,297 | 39,973 | 39,887 | 40,185 | 347,647 | |
| New HF, n (%) | 3547 (9.1) | 3235 (8.7) | 3221 (8.7) | 3106 (8.3) | 3214 (8.5) | 3326 (8.5) | 3388 (8.5) | 3433 (8.6) | 3459 (8.6) | 29,929 (8.6) | 0.021 |
AF, atrial fibrillation; HF, heart failure.
∗
P value from Cochrane Armitage trend test.
†
Excluding patients with previous 2-year history of HF/HF during the index AF episode.