TABLE 2.
Top 5 genes (according to R‐value) with increased/decreased RNA representation in function of age identified within the GV/IVM‐MII population independently
| Gene name | Description | R value | p‐value |
|---|---|---|---|
| Top 5 GV up | |||
| ENSG00000278292 | Ret Finger Protein Like 4A Pseudogene 6 | 0.6294745 | 5.09827E−05 |
| UBE2Q2P1 | Ubiquitin Conjugation Enzyme E2 Q2 Pseudogene 1 | 0.58455502 | 0.000226527 |
| WFIKKN2 | WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 2 | 0.58369917 | 0.000232566 |
| LINC02022 | Long Intergenic Non‐Protein Coding RNA 2022 | 0.57281807 | 0.000322912 |
| ENSG00000227240 | lncRNA, new transcript | 0.000322912 | 0.000339781 |
| Top 5 GV down | |||
| NNT | Nicotinamide Nucleotide Transhydrogenase | −0.5872276 | 0.000208561 |
| DCK | Deoxycytidine Kinase | −0.5281484 | 0.001110088 |
| KAT8 | Lysine Acetyltransferase 8 | −0.5205088 | 0.001348543 |
| RGS18 | Regulator Of G Protein Signaling 18 | −0.4935282 | 0.002589092 |
| ARHGEF26 | Rho Guanine Nucleotide Exchange Factor 26 | −0.4934728 | 0.002592426 |
| Top 5 IVM‐MII up | |||
| NOL8 | Nucleolar Protein 8 | 0.672405618 | 3.42412E−05 |
| TNIK | TRAF2 And NCK Interacting Kinase | 0.661684117 | 5.04619E−05 |
| ESCO2 | Establishment Of Sister Chromatid Cohesion N‐Acetyltransferase 2 | 0.650871928 | 7.3487E−05 |
| AFDN | Afadin, Adherens Junction Formation Factor | 0.638270876 | 0.000111848 |
| TPR | Translocated Promoter Region, Nuclear Basket Protein | 0.634740326 | 0.0001254 |
| Top 5 IVM‐MII down | |||
| PIN1 | Peptidylprolyl Cis/Trans Isomerase, NIMA‐Interacting 1 | −0.632135194 | 0.00013632 |
| SERF2 | Small EDRK‐Rich Factor 2 | −0.621504263 | 0.000190188 |
| C12orf75 | Chromosome 12 Open Reading Frame 75 | −0.620631179 | 0.000195356 |
| TLR5 | Toll Like Receptor 5 | −0.605605391 | 0.000306149 |
| KIAA1671 | Uncharacterized Protein KIAA1671 | −0.588558598 | 0.000496349 |
| Gene name | Description | R value | p‐value | ||
|---|---|---|---|---|---|
| GV | IVM‐MII | GV | IVM‐MII | ||
| Examples of genes with increased transcript representation with age | |||||
| FAM201B | Family With Sequence Similarity 210 Member B | 0.36 | 0.44 | 0.03 | 0.01 |
| TERB1 | Telomere Repeat Binding Bouquet Formation Protein 1 | 0.36 | 0.38 | 0.03 | 0.03 |
| RFC1 | Replication Factor C Subunit 1 | 0.42 | 0.45 | 0.01 | 0.01 |
| Examples of genes with decreased transcript representation with age | |||||
| ND1 | Mitochondrially Encoded NADH: Ubiquinone Oxidoreductase Core Subunit 1 | −0.35 | −0.47 | 0.04 | 0.01 |
The rest of genes, together with the R and p‐values can be found in Table S4.