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S1P and dhS1P levels. MCF-7L cells were transfected with WT GFP-mSK1 or T1-T5 GFP-mSK1 mutants or K49E GFP-mSK1 mutant or I51C GFP-mSK1 mutant and S1P levels measured by LC-MS/MS. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 for SK1 (WT or mutant) transfected versus GFP transfected (unpaired t test); +++p < 0.0001 for T5 mutant versus WT SK1 transfected (unpaired t test) for triplicate samples. mSK1, mouse SK1; S1P, sphingosine-1-phosphate.
