Table 4. Univariate and Multivariate Analysis of Variables for Association With HGD.
| Variables | Patient groupa | P value | OR (95% CI)b | P value | |
|---|---|---|---|---|---|
| LGD (n = 185) | HGD (n = 63) | ||||
| Surveillance time, median (IQR), mo | 38 (20-70) | 34 (17-59) | .09 | NA | NA |
| Age at diagnosis, median (IQR), y | 63 (56-72) | 66 (58-74) | .23 | NA | NA |
| Diameter, median (IQR), mm | |||||
| Initial | 20 (13-28) | 25 (15-35) | .10 | NA | NA |
| Final | 30 (20-37) | 32 (21-45) | .09 | NA | NA |
| Growth rate, mm/y | |||||
| Median (IQR) | 1.32 (0-3.2) | 1.62 (0-4.3) | .62 | NA | NA |
| ≥5 | 58 (31.4) | 25 (39.7) | .28 | NA | NA |
| Size ≥30 mm | 89 (48.1) | 33 (52.4) | .47 | NA | NA |
| Pancreatitis | 39 (21.1) | 21 (33.3) | .06 | NA | NA |
| Jaundice | 1 (0.5) | 0 | NA | NA | NA |
| Thick walls | 28 (15.1) | 7 (11.1) | .53 | NA | NA |
| MPD, mm | |||||
| 5-9 | 67 (36.2) | 30 (47.6) | .10 | NA | NA |
| ≥10 | 23 (12.4) | 14 (22.2) | .06 | NA | NA |
| Nonenhancing mural nodule | 31 (16.8) | 13 (20.6) | .33 | NA | NA |
| Enhancing mural nodule | 4 (2.2) | 5 (7.9) | .046 | NA | NA |
| WF at diagnosis | 70 (37.8) | 34 (54.0) | .03 | NA | NA |
| WF developed during surveillance | |||||
| Additional | 20 (10.8) | 13 (20.6) | .047 | 2.43 (1.12-5.28) | .03 |
| New | 72 (38.9) | 15 (23.8) | .03 | 0.66 (0.32-1.33) | .24 |
| HRS at diagnosis | 9 (4.8) | 6 (9.5) | >.99 | ||
| From WF to HRS during surveillance | 8 (4.3) | 8 (12.7) | .02 | 3.74 (1.33-10.55) | .01 |
Abbreviations: HGD, high-grade dysplasia; HRS, high-risk stigmata; IQR, interquartile range; LGD, low-grade dysplasia; MPD, main pancreatic duct; NA, not applicable; OR, odds ratio; WF, worrisome feature.
a
Unless otherwise indicated, data are expressed as number (percentage) of patients.
b
After a collinearity assessment, only 3 variables were evaluated through a binary logistic regression model.