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. Author manuscript; available in PMC: 2022 Apr 15.
Published in final edited form as: Cell. 2021 Mar 17;184(8):2121–2134.e13. doi: 10.1016/j.cell.2021.02.049

Figure 3: Coupling region interactions and conformational differences.

Figure 3:

A, Alignments of amino acids from α subunits in the nicotinic receptor family for coupling regions. B-D, The coupling region in resting (B), activated (C), and desensitized (D) conformations. Dashed lines indicate electrostatic interactions with distances in Angstrom (Å).