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. 2021 Apr 8;20(5):e13355. doi: 10.1111/acel.13355

FIGURE 4.

FIGURE 4

Classification of modification‐specific biomarker candidates into protein classes reveals ECM components, ROS‐ and protease‐modifying enzymes, cytoskeletal proteins and ribosomal proteins as the classes most affected by photoageing. Proteins with photoageing‐specific modifications were categorised into protein classes (PANTHER classification system; large multi‐coloured pie charts). The top four classes for dermis (a) were as follows: ECM proteins (blue slice), metabolite interconversion enzymes (orange slice), cytoskeletal proteins (grey slice) and protein activity modulators (yellow slice). Cytoskeletal proteins and metabolite interconversion enzymes were also in the top four classes for the epidermis (b) in addition to translational proteins (brown slice) and nucleic acid binding proteins (dark blue slice). Protein identities contained within sub‐categories are also listed