TABLE 1.

Fifteen of the most significant Reactome pathways derived by enrichment analysis of photoageing biomarker candidates identified in skin by peptide location fingerprinting (selected from the top 25)

Dermis	Pathway name	Entities found	Entities FDR
1	Extracellular matrix organization	27	1.50E−13
2	Integrin cell surface interactions	10	1.46E−09
3	Neutrophil degranulation	26	1.46E−09
4	Assembly of collagen fibrils and other multimeric structures	12	5.61E−09
5	ECM proteoglycans	13	4.88E−08
6	Formation of tubulin folding intermediates by CCT/TriC	8	7.70E−08
7	Prefoldin mediated transfer of substrate to CCT/TriC	8	1.17E−07
8	Defective CFTR causes cystic fibrosis	4	5.98E−07
9	Immune System	56	5.98E−07
10	Chaperonin‐mediated protein folding	11	5.98E−07
11	Collagen degradation	9	5.98E−07
12	Collagen formation	13	1.10E−06
13	ABC transporter disorders	4	1.30E−06
14	Platelet degranulation	10	1.82E−06
15	Degradation of the extracellular matrix	13	2.20E−06

Epidermis	Pathway name	Entities found	Entities FDR
1	Formation of the cornified envelope	18	2.25E−10
2	Neutrophil degranulation	22	1.12E−08
3	Keratinization	18	1.39E−08
4	L13a‐mediated silencing of Ceruloplasmin expression	12	6.99E−08
5	Formation of a pool of free 40S subunits	11	2.72E−07
6	SRP‐dependent cotranslational protein targeting to membrane	11	5.09E−07
7	GTP hydrolysis and joining of the 60S ribosomal subunit	12	1.13E−06
8	Eukaryotic Translation	12	2.89E−06
9	Selenocysteine synthesis	10	2.91E−06
10	Peptide chain elongation	10	9.78E−06
11	Regulation of expression of SLITs and ROBOs	13	1.04E−05
12	Cap‐dependent Translation Initiation	12	2.94E−05
13	Selenoamino acid metabolism	11	2.94E−05
14	Nonsense‐Mediated Decay (NMD)	10	2.07E−04
15	Type I hemidesmosome assembly	5	4.39E−04