Table 1.

Potential interventions for microglia polarization after intracerebral hemorrhage.

Phenotype	Activating signals (events)	Markers (events)	Result	Purpose
Pro-inflammatory microglia	JNK (TO901317, HBOP -)GSK-3β (Lithium, BIO -) miR-222 (Fisetin -) TLR4 (Ligustilide, Senkyunolide H, MPSS, Eupatilin -)miR-124 TREK-1	MMP (Minocycline, sinomenine -) Caspase-1 (AC-YVAD-CMK, Fimasartan -) TNF-αIL-1βNF-κB (ITGB8, Andrographolide -) IL-6 IL-1	Pro-inflammation	Neurological deficit
Anti-inflammatory microglia	TregsAMPK (CTRP9, AdipoR1 +)IL-33	TGF-βIL-10 (Atorvastatin +)Tregs MC4R (RO27-3225 +)	Phagocytosis Anti-inflammation	Neurological recovery