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P-gp inhibition causes increased accumulation of paclitaxel in SH-SY5Y-derived neurons. Fully differentiated SH-SY5Y cells were treated with the indicated concentrations of paclitaxel for 1 hour in the absence and presence of 4 μM valspodar. The values shown are triplicates from one differentiation and are increased in the presence of valspodar (p<0.001, ANOVA).
