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. 2021 May 13;22(1):761. doi: 10.3892/etm.2021.10193

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Overexpression of circSKIL promotes the osteogenic differentiation and activates the JNK/STAT3 pathway in control cells. Control cells were transfected with either a circSKIL-overexpressing plasmid or an empty vector (NC). (A) mRNA expression levels of RUNX2, ALP, COL I, OCN, and OPN (n=3). (B) Western blot analysis of the protein expression levels of RUNX2, ALP, COL1A1, OCN, and OPN (n=3). (C) Western blot analysis of the protein levels of p-JNK, JNK, p-STAT3, and STAT3 (n=3). ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs. NC. circ, circular RNA; NC, negative control; RUNX2, runt-related transcription factor 2; ALP, alkaline phosphatase; COL I, collagen I; OCN, osteocalcin; OPN, osteopontin; COL1A1, collagen type I α 1 chain; p-, phosphorylated.