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. 2021 May 19;21:172. doi: 10.1186/s12890-021-01539-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Kaplan–Meier curves for PFS. The median PFS was 4.5 months (95% CI, 3.5–5.7) for OSI and 3.9 months (95% CI, 3.1–4.8) for AFA. A significant difference was detected in the median PFS between groups. *HR was calculated using the Cox proportional hazards model, with age, sex and time span of smoking history as covariates and OSI/AFA therapy as the time-dependent factor. With respect to PFS, the results were analysed using the log-rank test (p = 0.014)