Table 2.
Drug-related adverse events
| Variable | OSI (n = 85 AEs involving 48 patients) | AFA (n = 109 AEs involving 59 patients) | p valuea | ||||
|---|---|---|---|---|---|---|---|
| All grades (%) | ≥ Grade 3 (%) | All grades (%) | ≥ Grade 3 (%) | All grades (%) | ≥ Grade 3 (%) | ||
| Diarrhoea | 24 (28.2) | 8 (9.4) | 47 (43.1) | 25 (22.9) | 0.03* | 0.13 | |
| Rash | 22 (25.9) | 5 (5.9) | 18 (16.5) | 7 (6.4) | 0.11 | 0.88 | |
| Dry skin | 18 (21.2) | 6 (7.1) | 12 (11.0) | 5 (4.6) | 0.52 | 0.46 | |
| Paronychia | 11 (12.9) | 0 (0.0) | 6 (5.5) | 0 (0.0) | 0.07 | NA | |
| Alopecia | 3 (3.5) | 0 (0.0) | 15 (13.8) | 6 (5.5) | 0.02* | 0.03* | |
| Asthenia | 2 (2.4) | 0 (0.0) | 6 (5.5) | 0 (0.0) | 0.27 | NA | |
| Decreased appetite | 5 (5.8) | 0 (0.0) | 5 (4.6) | 0 (0.0) | 0.69 | NA | |