Table 1.
Patient characteristics.
Patient no. | Sex | Age (years) | First diagnosis | Diagnosis | EDSS | Last OCR/RTX infusion | Start of OCR/RTX treatment | PCR test | Antibody test | SARS-CoV-2 IgG anti-Nucleocapsid | SARS-CoV-2 IgG anti-Spike protein | Symptoms | Management | Previous DMT (sequence) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 37 | 2018 | RRMS | 1.5 | 10 July 2020 | January 2019 | 20 October 2020 | 26 November 2020 | Negative | Negative | Bilateral pneumonia | In-patient treatment | None |
2 | F | 39 | 2009 | RRMS | 4 | 8 July 2020 | May 2018 | 17 October 2020 | 09 December 2020 | Negative | Negative | Pneumonia | Out-patient treatment | Interferon beta 1a, Natalizumab, Interferon beta 1b, Natalizumab, Glatirameracetate, Rituximab |
3 | F | 55 | 2003 | RRMS | 3 | 12 June 2020 | April 2018 | 27 September 2020 | 10 February 2021 | Negative | Negative | Pneumonia | Out-patient treatment | Interferon beta 1a, Interferon beta 1b, Glatirameracetate, Natalizumab |
4 | F | 53 | 2004 | RRMS | 4 | 4 June 2020 | September 2018 | 23 October 2020 | 8 February 2021 | Negative | Negative | Sepsis | In-patient treatment | Interferon beta 1a, Glatirameracetate, Natalizumab |
5a | F | 44 | 2017 | NMOSD | 3 | 3 July 2020 | June 2017 | 3 December 2020 | 27 January 2021 | Negative | Negative | Bilateral pneumonia | In-patient treatment | Interferon beta 1a, Fingolimod, Daclizumab |
6 | M | 47 | 2020 | RRMS | 1 | 14 August 2020 | July 2020 | 30 December2020 | 17 February 2021 | Negative | Negative | Pneumonia | Out-patient treatment | None |
7 | M | 53 | 2014 | PPMS | 2.5 | 3 September 19 | March 2019 | 31 March 2020 | 23 December 2020 | Negative | Positive | Sepsis | In-patient treatment | None |
8 | F | 69 | 2004 | SPMS | 4.5 | 7 February 2020 | August 2017 | 7 December 2020 | 10 February 2021 | Positive | Positive | Pneumonia | Out-patient treatment | Interferon beta 1b |
Patient 5 has first been diagnosed and treated with an RRMS diagnosis and was classified as NMOSD in 2017.
DMT, disease modifying treatment; EDSS, expanded disability status scale; NMOSD, neuromyelitis optica spectrum disorder; OCR, ocrelizumab; PPMS, primary progressive multiple sclerosis; RTX, rituximab; SARS-CoV-2, severe acute respiratory syndrome corona virus 2; RRMS, relapsing remitting multiple sclerosis; SPMS, secondary progressive multiple sclerosis.