Figure 6.

Stratification of patients in subgroups. (a) Illustrative graph with different colors showing the various subgroups of patients included in the present study. Group A consisted of patients presented with Marburg-like TDL (n = 4). Groups B and C consisted of patients presented with monophasic (n = 7) and recurrent TDL (n = 12), respectively. Group D consisted of MS patients that subsequently developed TDL (n = 16) during MS disease course. Group E comprised patients initially presenting with TDL and subsequently developing MS without evidence of TDL (n = 5). Groups D (n = 2) and F (n = 4) involved patients with MS who developed TDL during drug initiation (natalizumab, fingolimod) and cessation, (interferon/possible, fingolimod) respectively. (b) Graph showing the EDSS score of each subgroup analyzed at TDL onset, after acute treatment (less that 3 months of disease initiation), and after the last follow-up. Statistically significant differences in the EDSS scores among the various time points in each subgroup are depicted in the figure. GraphPad was applied for image making and statistical analysis.

EDSS, Expanded Disability Status Scale; MS, multiple sclerosis; TDL, tumefactive demyelinating lesion.