Table 6.

Pharmacological Active Dose and Exposure in Mice.

Tumor model	Dose range (mg/kg)	PADa	Predicted exposure (Cavg) at PADb
Cloudman S91	3, 10, and 30 mg/kg	3 mg/kg	28.4 μg/mL
MBT-2	3 and 10 mg/kg	10 mg/kg	86.3 μg/mL
EMT-6	10 mg/kg	10 mg/kg	86.3 μg/mL

Abbreviations: PAD, pharmacological active dose; PK, pharmacokinetics.

^a Pharmacological active dose determined from multidose in vivo efficacy studies in Martin 2020.

^b Single-dose PK data in mice (Table 4) were used to predict the multidose PK exposure at PAD.