Figure 3. Transcriptional regulation of secretory capacity and the secretome.

(A) CrebA increases secretory capacity by direct binding and activation of core secretory pathway component genes (SPCGs), Xbp1, and TSN. Fkh works with Sage and Sens to control what is made in and secreted from the SG (cargo) and how cargo is modified as it goes through the secretory pathway. Fkh, Sage and Sens also block apoptotic cell death by blocking expression of pro-apoptotic genes rpr and hid. B. Cartoon showing the organelles of the secretory system and what secretory processes are transcriptionally regulated by CrebA.