Table 5.
Univariate and Multivariable Analysis by Linear Regression on Factors Associated With Trough Ct Value of RT-PCR of SARS-CoV-2 During COVID-19 Infection
| Univariate Analysis | Multivariable Analysis | |||
|---|---|---|---|---|
| Parameters | Coefficient (95% CI) | P Value | Adjusted Coefficient (95% CI) | P Value |
| ALT/AST elevation | –2.292 (–2.674 to –1.909) | <.001 | –0.764 (–1.141 to –0.387) | <.001 |
| Age | –0.079 (–0.087 to –0.072) | <.001 | –0.039 (–0.047 to –0.031) | <.001 |
| Male gender | –0.528 (–0.823 to –0.232) | <.001 | ||
| Liver cirrhosis | –3.358 (–4.740 to –1.976) | <.001 | –1.485 (–2.793 to –0.178) | .026 |
| Diabetes mellitus | –2.441 (–2.835 to –2.047) | <.001 | ||
| Hypertension | –2.439 (–2.776 to –2.101) | <.001 | ||
| Use of corticosteroids | –3.564 (–3.949 to –3.179) | <.001 | ||
| Use of remdesivir | –4.039 (–4.591 to –3.487) | <.001 | –2.460 (–3.005 to –1.914) | <.001 |
| Use of other antiviral agents for COVID-19 | –3.976 (–4.265 to –3.687) | <.001 | –3.077 (–3.389 to –2.765) | <.001 |
ALT and/or AST elevation was defined by ALT and/or AST ≥2× the upper limit of normal at baseline or during follow-up. The upper limit of normal of ALT and AST was 40 U/L. Other antiviral agents for COVID-19 included interferon-beta, lopinavir-ritonavir, and/or ribavirin.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; COVID-19, coronavirus disease 2019; Ct, cycle threshold; RT-PCR, reverse transcription polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.