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. 2021 Apr 27:bbab118. doi: 10.1093/bib/bbab118

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© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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The model shows that ZNF proteins of COVID-19 patients of different genders resist SARS-CoV-2 infection through TF activity and antiviral activity. The solid line represents the well-known regulatory relationship, and the dashed line represents the regulatory relationship speculated based on our analysis results and existing literature. The sharp arrow indicates activation, and the flat arrow indicates inhibition.