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. 2021 Apr 27:bbab118. doi: 10.1093/bib/bbab118

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© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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The similarities and differences in the functions and activities of ZNF proteins in COVID-19 patients of different genders. (A) The Venn diagram shows the common and specific ZNF proteins of different genders. (B) The difference in protein activity of the 5 shared ZNF proteins after different genders were infected with the coronavirus SARS-CoV-2. The horizontal axis represents the normalized enrichment score used to predict the protein activity of ZNF proteins. The larger the value, the stronger the protein activity. The vertical axis represents the number of MRs. The red and green lines represent the median value. (C) The heat map shows the expression changes of differentially expressed ZNF proteins in normal women and COVID-19 women. (D) The heat map shows the expression changes of differentially expressed ZNF proteins in normal women and COVID-19 men. (E) Differences in the overall ZNF protein activity among COVID-19 patients of different genders. The ssGSEA algorithm was used to calculate the overall expression activity of ZNF family genes. (F) The violin chart shows the expression of marker genes in different cell populations. For more information and marker combinations, please refer to Figure S4, see Supplementary Data available online at http://bib.oxfordjournals.org/, and its legend. (G) UMAP cluster diagram shows the cell population identification of single cell sequencing of all samples.