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. Author manuscript; available in PMC: 2021 May 20.
Published in final edited form as: Nat Immunol. 2020 May 4;21(6):605–614. doi: 10.1038/s41590-020-0677-6

Table 2 |.

MicroRNAs control aspects of the immune response and organ damage in SLE

MicroRNA Function Ref.
miR-146a Regulates the innate immune response 145
miR-125a Regulates the anti-inflammatory response 146
miR-155 Controls the expression of SH2-domain-containing inositol 5′-phosphatase 1 (SHIP1), which is important in B cell activation; miR155−/−Faslpr mice have decreased autoimmunity and nephritis 147
miR-148a Impairs B cell tolerance by suppressing the expression of the autoimmune suppressor Gadd45a, the tumor suppressor PTEN and the proapoptotic protein Bim, which promotes the survival of immature B cells after engagement of the B cell antigen receptor 148
miR-23b Suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKKα mRNA 149
miR-17[sim]92 Promotes TFH cell differentiation; promotes DC activation through the microRNA let-7c and BLIMP-1 150
151
miR-150 Promotes renal fibrosis in lupus nephritis by downregulating expression of SOCS1 152