Figure 3.

Dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNAemia and clinical severity, by modified World Health Organization (WHO) score. A, Serial plasma SARS-CoV-2 RNA concentrations and WHO scores for each of the 27 patients with longitudinal samples. Plasma RNA concentration (red gradient) and WHO scores (blue gradient) are shown with respect to the number of days since the reported onset of symptoms (not date of study enrollment) for each patient. Numbers of patients who died in the hospital are highlighted in boldface and italic. Specimens with undetectable RNAemia are represented with x’s. Fourteen of 27 patients had undetectable RNAemia by day 10, while the same proportion took 16 days to reach maximum severity, and 33 days for resolution of symptoms. B, Aggregate RNA and clinical dynamics in the 30 days after onset of symptoms. Loess regression curves represent trends in RNA and clinical dynamics. RNAemia peaked 3 days after symptom onset, while clinical severity peaked at 14 days.