Table 1.
Study and patient characteristics for the 65 delirium trials
| Overall | Prevention | Treatment | Both | |
|---|---|---|---|---|
| n = 65 | n = 44 | n = 12 | n = 9 | |
| Study characteristics | ||||
| Sample size, median [Q1,Q3] | 113 [70, 198] | 109 [70, 158] | 104 [72, 238] | 141[101, 164] |
| Study start year, median [Q1, Q3] | 2012 [2009, 2014] | 2013 [2009, 2014] | 2009 [2005, 2012] | 2010 [2009, 2011] |
| Fundinga | ||||
| Governmental funding | 20 (31) | 9 (21) | 5 (42) | 6 (67) |
| No external funding | 18 (28) | 12 (27) | 3 (25) | 3 (33) |
| Industry funding | 8 (12) | 5 (11) | 2 (17) | 1 (11) |
| Non-profit sources (non-govt) | 5 (8) | 3 (7) | 2 (17) | 0 (0) |
| Other source of funding | 7 (11) | 6 (14) | 0 (0) | 1 (11) |
| Unclear funding source | 16 (25) | 13 (30) | 3 (25) | 0 (0) |
| Country/regiona | ||||
| USA | 16 (25) | 10 (23) | 4 (33) | 2 (22) |
| China | 12 (19) | 10 (23) | 1 (8) | 1 (11) |
| Iran | 8 (12) | 7 (16) | 1 (8) | 0 (0) |
| Canada | 5 (8) | 4 (9) | 1 (8) | 0 (0) |
| Europeb | 5 (8) | 2 (5) | 0 (0) | 3 (33) |
| Japan | 2 (3) | 2 (5) | 0 (0) | 0 (0) |
| Otherc | 21 (32) | 12 (27) | 5 (42) | 3 (33) |
| Patient typea,e | ||||
| Cardiac surgery | 22 (34) | 16 (36) | 3 (25) | 3 (33) |
| Surgery | 19 (29) | 15 (34) | 3 (325) | 1 (11) |
| ARFf | 17 (26) | 10 (23) | 3 (25) | 4 (44) |
| Medical | 6 (9) | 2 (5) | 3 (25) | 1 (11) |
| Other | 14 (22) | 6 (14) | 6 (50) | 2 (22) |
| ICU typea | ||||
| General or mixedd | 13 (20) | 6 (14) | 4 (33) | 3 (33) |
| Surgical | 11 (17) | 6 (14) | 4 (33) | 1 (11) |
| Cardiovascular surgery | 10 (15) | 10 (23) | 0 (0) | 0 (0) |
| Medical | 9 (14) | 4 (9) | 4 (33) | 1 (11) |
| Coronary care | 1 (2) | 0 (0) | 0 (0) | 1 (11) |
| Unspecified | 28 (43) | 20 (46) | 5 (42) | 3 (33) |
| Patient characteristics | ||||
| Average age, median [Q1,Q3] | 62 [59, 69] | 63 [59, 69] | 62 [55, 65] | 66 [63, 68] |
| Proportion male, median [Q1,Q3] | 62 [53, 72] | 63 [55, 70] | 61 [51374] | 58 [50, 60] |
| Severity of illness measurea | ||||
| APACHE II | 23 (35) | 13 (29.5) | 7 (58) | 3 (33) |
| APACHE III | 2 (3) | 1 (2) | 0 (0) | 1 (11) |
| APACHE IV | 1 (2) | 1 (2) | 0 (0) | 0 (0) |
| SAPS II | 1 (2) | 1 (2) | 0 (0) | 0 (0) |
| SAPS III | 1 (2) | 1 (2) | 0 (0) | 0 (0) |
| SOFA | 6 (9) | 4 (9) | 1 (8) | 1 (11) |
| Average APACHE II, median [Q1,Q3] | 15 [11, 20] | 15 [11, 18] | 13 [11, 20] | 20 [18, 21] |
| Average SOFA, median [Q1,Q3] | 5 [4, 7] | 4 [4, 5] | 6 [6, 6] | 9 [9, 9] |
Values in the table are count (%) unless otherwise noted. The RCTs may be counted in several categories for each characteristic, so that the count (%) will not necessarily sum to 65 (100%)
Abbreviation: ARF Acute respiratory failure
aMultiple categories could be selected for each delirium RCT, so that the count (%) will not necessarily sum to 65 (100%)
bEurope includes Switzerland (1 prevention trial), Italy (1 prevention trial, 1 prevention/treatment trial), and Great Britain (2 prevention/treatment trials)
cOther includes Egypt (3), Netherlands (3), Turkey (3), South Korea (2), Thailand (2), Australia (1), Belgium (1), Chile (1), India (1), Saudia Arabia (1), and Serbia (1)
dMixed ICU is a medical-surgical ICU
eCardiac surgery and general surgery are mutually exclusive. If a trial recruited both cardiac and non-cardiac surgery patients, it was classified as general surgery. Surgery includes patients with a trauma designation
fAcute respiratory failure includes trials conducted among mechanically ventilated, acute respiratory, or acute respiratory distress syndrome patients