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. 2021 May 17;48(1):130. doi: 10.3892/ijmm.2021.4963

Figure 5.

Figure 5

Effect of AST on FLS proliferation and cell cycle with lncRNA LOC100912373 overexpression. (A) lncRNA LOC100912373 expression levels following transfection with overexpression plasmid was detected by RT-qPCR. ##P<0.01, compared with the model group. (B) FLS inhibition rate between groups, under a 48-h intervention time. ##P<0.01, compared with the model group; **P<0.01, compared with the lncRNA LOC100912373 overexpression group. (C) Cell cycle phase was detected by flow cytometry. (a) Control group; (b) model group; (c) lncRNA LOC100912373 overexpression group; (d) AST group; (e) lncRNA LOC100912373 overexpression and AST intervention group; (f) NC group. (D) Cell cycle quantification. #P<0.05, compared with the control group; ##P<0.01, compared with the control group; *P<0.05, compared with the control group; **P<0.01, compared with the model group; ΔΔP<0.01, compared with the lncRNA LOC100912373 overexpression group. ALS, astragaloside; FLS, fibroblast-like synoviocyte.