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. 2021 May 20;21:577. doi: 10.1186/s12885-021-08332-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — a Expression of PDE9A in different cancers from Oncomine database with significant mRNA depending on different types of cancer and corresponding normal tissue. Here, upregulation is marked in red and downregulation is blue. The threshold parameters were set as follows: P-value of 1E− 4, fold change 2, gene ranking 10%. b-m box plot comparing PDE9A expression in different colorectal cancer types (normal tissue in left and cancerous tissue in right) depicted significant downregulation of PDE9A in b Colorectal Adenoma (COA), c Rectal Mucinous Adenocarcinoma (REMAD), d Cecum Adenocarcinoma (CEAD), e Rectal Adenocarcinoma (READ), f Colon Mucinous Adenocarcinoma (COMAD), g Colon Adenocarcinoma (COAD), h Colon Adenoma (COA), i Colon Carcinoma (COCA), j Colon Adenoma (COA), k Colorectal Carcinoma, l Rectal Adenocarcinoma (READ), m Colorectal Carcinoma