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. Author manuscript; available in PMC: 2021 May 20.
Published in final edited form as: Biol Psychiatry. 2019 Nov 1;88(2):169–184. doi: 10.1016/j.biopsych.2019.10.015

Table 1:

Loci genome-wide significant (p < 5×10−8) in the MOOD meta-analysis.

Locus Chr BP Index SNP A1 A2 OR SE p Previous report
1 1 37192741 rs1002656 T C 0.97 0.005 2.71×10−11 DO, N
2 1 72837239 rs7531118 T C 0.96 0.004 1.05×10−16 D, DO, S, O
4 1 80795989 rs6667297 A G 0.97 0.005 5.86×10−11 D, DO
5 1 90796053 rs4261101 A G 0.97 0.005 1.78×10−8 D
6 1 175913828 rs10913112 T C 0.97 0.005 1.46×10−10 DO, O
7 1 177370033 rs16851203 T C 0.96 0.007 2.38×10−9 DO, S, O
9 2 22582968 rs61533748 T C 0.97 0.004 3.84×10−11 DO, N
10 2 57987593 rs11682175 T C 0.97 0.004 2.18×10−11 D, DO, BS, N, S, O
11 2 157111313 rs1226412 T C 1.03 0.005 1.27×10−8 D, DO, N, O
12 2 198807015 rs1518367 A T 0.97 0.005 1.18×10−8 BS, S, O
13 3 108148557 rs1531188 T C 0.96 0.006 1.61×10−9 O
14 3 158107180 rs7430565 A G 0.97 0.004 2.30×10−11 D, DO, N, O
16 4 42047778 rs34215985 C G 0.97 0.006 1.72×10−10 D, DO, N
17 5 77709430 rs4529173 T C 0.97 0.005 4.29×10−9 O
18 5 88002653 rs447801 T C 1.03 0.004 2.29×10−10 D, DO, N, O
19 5 92995013 rs71639293 A G 1.03 0.005 5.85×10−9 DO, N
20 5 103904226 rs12658032 A G 1.04 0.005 2.19×10−16 D, DO, N, O
21 5 106603482 rs55993664 A C 0.97 0.006 1.87×10−8 NOVEL LOCUS
22 5 124251883 rs116755193 T C 0.97 0.005 1.47×10−10 D, O
23 5 164523472 rs11135349 A C 0.97 0.004 2.96×10−11 D, DO, N
24 5 166992078 rs4869056 A G 0.97 0.005 5.21×10−9 D
25 6 28673998 rs145410455 A G 0.94 0.007 7.17×10−18 D, DO, BO, BS, DS, N, S, O
26 6 101339400 rs7771570 T C 0.97 0.004 9.68×10−10 DO, N, O
27 6 105365891 rs1933802 C G 0.98 0.004 1.05×10−8 DO, S, O
28 7 12267221 rs4721057 A G 0.97 0.004 7.31×10−11 D, DO, N, O
29 7 24826589 rs79879286 C G 1.04 0.006 1.97×10−11 B, BS, DO, S
30 7 82514089 rs34866621 T C 1.03 0.005 2.21×10−8 DO, O
31 7 109099919 rs58104186 A G 1.03 0.004 7.12×10−9 D, DO
34 9 11379630 rs10959753 T C 0.96 0.005 1.45×10−13 D, DO, N, O
35 9 37207269 rs4526442 T C 0.96 0.006 7.97×10−11 DO, O
36 9 81413414 rs11137850 A G 1.03 0.005 1.25×10−8 NOVEL LOCUS
38 9 119733380 rs10759881 A C 1.03 0.005 8.56×10−9 D, DO
40 9 122664468 rs10818400 T G 0.98 0.004 1.29×10−8 N
41 9 126682068 rs7029033 T C 1.04 0.008 2.61×10−8 D, DO, O
42 10 104684544 rs78821730 A G 0.96 0.007 2.95×10−8 N, BS, S, O
43 10 106563924 rs61867293 T C 0.96 0.005 5.64×10−12 D, DO, N, O
44 11 16293680 rs977509 T C 0.97 0.005 1.19×10−8 DO, N, O
45 11 31850105 rs1806153 T G 1.03 0.005 2.81×10−9 D, DO, N, O
46 11 32765866 rs143864773 T C 1.04 0.008 1.70×10−8 NOVEL LOCUS
47 11 61557803 rs102275 T C 0.97 0.005 5.04×10−11 B, DO, BO, O
48 11 63632673 rs10792422 T G 0.98 0.004 2.18×10−8 O
49 11 88743208 rs4753209 A T 0.97 0.004 4.15×10−9 DO, N, O
50 11 99268617 rs1504721 A C 0.98 0.004 2.24×10−8 O
51 11 113392994 rs2514218 T C 0.97 0.005 3.22×10−10 DO, BS, N, S, O
52 12 2344644 rs769087 A G 1.03 0.005 3.27×10−8 B, BD, BO, DS, BS, S, O
53 12 23947737 rs4074723 A C 0.97 0.004 3.18×10−9 D, DO, N, O
54 12 121186246 rs58235352 A G 0.95 0.009 1.64×10−10 DO, O
55 12 121907336 rs7962128 A G 1.02 0.004 3.63×10−8 NOVEL LOCUS
56 13 44327799 rs4143229 A C 0.95 0.008 2.73×10−10 D
57 13 53625781 rs12552 A G 1.04 0.004 1.25×10−23 D, DO, O
58 14 42074726 rs61990288 A G 0.97 0.004 2.29×10−10 D, DO, O
60 14 64686207 rs915057 A G 0.98 0.004 1.92×10−8 D, DO, O
61 14 75130235 rs1045430 T G 0.97 0.004 9.83×10−11 D, DO, N, O
62 14 104017953 rs10149470 A G 0.97 0.004 1.15×10−10 D, DS, DO, BS, S, O
63 15 36355868 rs1828385 A C 0.97 0.004 1.15×10−8 NOVEL LOCUS
64 15 37643831 rs8037355 T C 0.97 0.004 4.09×10−15 D, DO, O
65 16 6310645 rs8063603 A G 0.97 0.005 5.36×10−11 D, DO
66 16 7667332 rs11077206 C G 1.03 0.004 5.49×10−10 D, DO, N, O
67 16 13038723 rs12935276 T G 0.97 0.005 4.75×10−10 D, DO, N, O
68 16 13750257 rs7403810 T G 1.03 0.005 7.52×10−11 DO, BS, S, O
69 16 72214276 rs11643192 A C 1.03 0.004 1.46×10−11 D, O
70 17 27363750 rs75581564 A G 1.04 0.006 2.47×10−10 D, DO, O
71 18 31349072 rs4534926 C G 1.03 0.004 9.14×10−9 DO, N
72 18 36883737 rs62099069 A T 0.97 0.004 9.52×10−10 D, O
73 18 42260348 rs117763335 T C 0.97 0.005 1.33×10−8 O
74 18 50614732 rs11663393 A G 1.03 0.004 1.56×10−10 D, DO, N, O
75 18 52517906 rs1833288 A G 1.03 0.005 4.54×10−8 D, DS, DO, N, S, O
76 18 53101598 rs12958048 A G 1.04 0.005 4.86×10−14 D, DO, BS, N, S, O
77 19 30939989 rs33431 T C 1.02 0.004 4.04×10−8 DO, O
78 20 45841052 rs910187 A G 0.97 0.005 3.09×10−9 DO, O
79 22 41621714 rs2179744 A G 1.03 0.005 3.83×10−12 D, B, DO, BS, N, S, O
80 22 42815358 rs7288411 A G 1.03 0.005 3.86×10−8 NOVEL LOCUS
81 22 50679436 rs113872034 A G 0.96 0.006 1.10×10−9 O

Locus – shared locus number for annotation (Supplementary Table 3), Chr – chromosome, BP – base position, A1 – effect allele, A2 – non-effect allele, Previous report – locus previously implicated in PGC MDD (D), PGC BD (B), previous combined studies of bipolar disorder and major depressive disorder (BD), other studies of major depressive disorder or depressive symptoms (DO), other studies of bipolar disorder (BO), previous combined studies of bipolar disorder and schizophrenia (BS), previous combined studies of major depressive disorder and schizophrenia (DS), neuroticism (N), schizophrenia (S), or other studies (O – see Supplementary Table 4).