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. 2021 May 19;9:24. doi: 10.1186/s40170-021-00258-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The effect of combination treatment on mitochondrial respiration, glycolysis and cellular energy production. UVW/NAT cells were treated with 3 Gy X-radiation, 1 mM metformin, or 5 mM 2DG as single agents or in combination for 24 h. Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells were then measured using a Seahorse XFe96 Analyser, the shift in cell energy phenotype following treatment is shown (a) The traces obtained (Supplementary Figure 6) were then used to calculate glycolytic rate (b), minimal and maximal respiratory capacity (c) and ATP production (d)