Figure 3: Disrupted circadian host loses synchronization between central and peripheral timing.
The time of dim light melatonin onset (DLMO) marker of the central clock was compared to the time of peak expression of SCFAs (the acrophase). By a circular to circular correlation, there was a significant correlation with DLMO and SCFA Acrophase in A) Day Workers (DW) pre alcohol, B) DW post one week of alcohol (0.5g/kg), and C) NW pre alcohol. In NW after one week of alcohol (0.5g/kg) that correlation was not significant.