Skip to main content
. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2021 Mar 15;56(3):221–235. doi: 10.1080/10409238.2021.1893641

Figure 6. Structure and mechanism of human SQOR, a sulfurtransferase (PDB: 6OI6).

Figure 6.

(a) Reaction mechanism of SQR. CT denotes charge transfer. (b) A unique trisulfide between Cys-201 and Cys-379 represents the redox-active motif in the active site of human SQOR. The FAD cofactor is shown in green. (c) Surface representation of SQOR reveals a large cavity leading to the active site in which Cys-379 (yellow) that transfers the sulfane sulfur to an external acceptor, is relatively surface exposed.