Table 1.

Physiological and Other Parameters Used

Parameter	Description	Units	Mean Value (*Varied by HTTK-pop (Ring, et al., 2017))	Reference
Qliverc	Total blood flow to the liver (arterial and gut)	L/h/kg body weight	3.6*	Davies et al. (1993)
QGFR	Flow to the glomerulus (glomerular filtration rate)	L/h/kg body weight	0.32*	Davies, et al. (1993)
$n_{celldensity}$	Hepatocellularity	Millions of cells per gram liver	110*	Carlile et al. (1997)
$V_{liverc}$	Volume of the liver	L/kg body weight	0.0245*	Davies, et al. (1993)
$d_{liver}$	Liver density	g/mL	1.05*	International Commission on Radiological Protection (1975)
hematocrit	Fraction of blood that is red blood cells	Fraction	0.43*	(Davies, et al., 1993)
Cprotein	Concentration of protein used in fup assay	μM	5	Methods