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. Author manuscript; available in PMC: 2021 May 20.
Published in final edited form as: Toxicol Sci. 2019 Dec 1;172(2):235–251. doi: 10.1093/toxsci/kfz205

Table 2.

Chemicals where Uncertainty in Data Changed Bioactivity:Exposure Ratio to be less than One

Chemical DSSTox Substance ID Clint (μL / min / 106 hepatocytes) fup In vitro Assays 10th Quantile (μM) Equivalent Dose - Variability Only (mg / kg body weight / day) Equivalent Dose - Uncertainty and Variability (mg / kg body weight / day) Exposure Upper 95th (mg /kg body weight / day)
2’,4’,5’,7’-Tetrabromofluorescein DTXSID3044590 0 3.00E-03 0.66 9.99E-04 6.17E-04 8.82E-04
2-Chloro-4-phenylphenol DTXSID0022353 49.2 1.17E-08 2.49 2.34E-03 5.61E-04 9.05E-04
3-Phenoxybenzoic acid DTXSID1038321 0 7.16E-03 0.56 7.72E-04 6.48E-04 7.09E-04
Dodecyltrimethylammonium chloride DTXSID1026900 16.2 3.64E-02 1.66 1.21E-01 9.91E-02 1.14E-01
N,N-Dimethyldodecan-1-amine DTXSID1026906 34.2 6.99E-03 3.84 1.21E-01 9.92E-02 1.08E-01
Tamoxifen DTXSID1034187 0 1.65E-03 0.92 4.25E-04 1.76E-04 1.82E-04