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. 2021 May 19;11:10597. doi: 10.1038/s41598-021-90094-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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BrdU-labeled mitochondria were expressed in striatal DA neurons and DCX-positive neurons of the anterior commissure (AC), defined by cross-sectional areas of the forebrain. (A) Double immunofluorescent staining of BrdU (red) with TH (green) was performed to confirm intranasally administered mitochondria in striatal DA neurons and (B) BrdU signals were quantified individually in lesioned and contralateral (intact) sides using ImageJ Software. (C) Reconfirmation of contralateral delivery of mitochondria employed double immunofluorescent staining, using BrdU (red) with DCX antibody (green) in the intact and lesioned sides of the AC, a bundle of axons connecting the two cerebral hemispheres. Images were taken at different magnifications in each group. (D) The merged image of Z-Stack confocal images, shown as side views of the x–z and y–z planes, revealed the localization of exogenous mitochondria in DCX-positive neurons. *P < 0.05, vs. Lesioned side, WT wild-type controls, Mito mitochondrial alone, P-Mito Pep-1-labelled mitochondria.