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. 2021 Jan 27;38(6):2209–2226. doi: 10.1093/molbev/msab018

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5. — Parallel evolution in nasopharynx-passaged pneumococci. (A) Muller plots showing the emergence and success of D39N_01029 (pvaA) variants in nasopharynx-passaged lineages 1 and 7. The pvaA-associated genotype is shown in teal. Additional colors are arbitrary but other successful genotypes or those originating from the ancestor population are labelled. (B) Genotype frequencies for lineages 1 and 7. (C) Muller plots showing the emergence and success of gpsA and yknX variants in nasopharynx-passaged lineages 3 and 4. The gpsA and yknX genotypes are shown in shades of green. The two variants are associated with a single genotype in lineage 3. A shared nonsynonymous variant in D39N_00558 is shown in purple. Additional colors are arbitrary. (D) Genotype frequencies for lineages 3 and 4.