Fig. 4.

Functional classification of genes involved in genetic transfers between distantly related phages. (A) Classification of typical phage functions using the pVOG database. (B) Classification of typical bacterial functions using the bactNOG database. In both panels, the size of each circle corresponds to the proportion of genes with a given function. The total number of genes with an assigned function is shown at the top. Enrichment (orange) or depletion (purple) of each function is assessed relatively to classification of all phage proteins with pVOG (in A) or bactNOG (in B). In both cases, the color intensity corresponds to the statistical significance of the classification (Fisher exact test adjusted for multiple comparisons with the Benjamini–Hochberg method).