Fig. 7.

Genetic transfers between temperate phages with different host genera through virulent phages. (A) Simplified network restricted to pairs of temperate–virulent phages where the virulent phage transferred genes from/to at least two temperate phages infecting distinct bacterial genera (i.e., edges shown are only those that link temperate phages with different hosts’ genera through a virulent phage). Each node color represents a different bacterial host genus, and the node sizes identify either temperate (large nodes) or virulent (small nodes) phages. Examples from panels (B) and (C) are highlighted in ellipses. (B) Examples of virulent phages (red) with genes transferred from/to two temperate phages (green) infecting distinct bacterial genera. (C) Analogous to (B), but representing transfers with the virulent phage that involve the exact same protein in both temperate phages. Colors in the blocks linking the phages indicate the level of sequence similarity between homologs. The genomic maps between each of the two temperate phages for each of the cases are shown in supplementary figure S20, Supplementary Material online.