Table 3.

Diagnostic performance of the three proposed models

Different models		Training cohort				Validation cohort
		Sensitivity	Specificity	Accuracy	AUC (95% CI)	Sensitivity	Specificity	Accuracy	AUC (95% CI)
Clinical	LGGs and HGGs	0.80	0.52	0.62	0.70 (0.59–0.80)	0.64	0.97	0.89	0.82 (0.66–0.99)
	Grade III and Grade IV	0.82	0.57	0.66	0.65 (0.51–0.78)	1.00	0.30	0.55	0.60 (0.39–0.80)
	Low Ki-67 LI and High Ki-67 LI	0.45	0.82	0.67	0.67 (0.56–0.77)	0.43	1.00	0.82	0.72 (0.54–0.90)
Radiomics	LGGs and HGGs	0.94	0.85	0.88	0.92 (0.87–0.97)	1.00	0.82	0.87	0.94 (0.87–1.00)
	Grade III and Grade IV	0.86	0.89	0.88	0.91 (0.83–0.99)	0.82	0.60	0.68	0.75 (0.57–0.93)
	Low Ki-67 LI and High Ki-67 LI	0.93	0.83	0.87	0.94 (0.89–0.98)	0.64	0.94	0.84	0.82 (0.69–0.96)
Combined	LGGs and HGGs	0.92	0.85	0.87	0.93 (0.89–0.98)	1.00	0.88	0.91	0.94 (0.87–1.00)
	Grade III and Grade IV	0.79	0.96	0.89	0.91 (0.83–0.99)	0.73	0.70	0.80	0.76 (0.58–0.94)
	Low Ki-67 LI and High Ki-67 LI	0.91	0.88	0.89	0.95 (0.91–0.99)	0.86	0.68	0.73	0.80 (0.66–0.94)

AUC, area under the curve; 95% CI, 95% confidence interval; LGGs, low-grade gliomas; HGGs, high-grade gliomas; Ki-67 LI, Ki-67 labeling index.