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. 2021 May 20;16(5):e0251917. doi: 10.1371/journal.pone.0251917

Table 2. PrEP use among participants.

Question Response N = 140
Are you currently using the 2-1-1 PrEP dosing method?, N (%)
Yes 107 (76.4)
No 33 (23.6)
Why have you decided to switch from once-daily oral PrEP to on-demand oral PrEP?, N (%)
Because I am having sex less frequently 89 (63.6)
Because I want to take fewer pills 65 (46.4)
Because I want to reduce the cost of my pills 31 (22.1)
Because I want fewer side effects 27 (19.3)
Because my partner(s) changed 6 (4.3)
Other 4 (2.9)
In the past 3 months, how many times have you taken on-demand dosing?, N (%)
0 16 (11.4)
1–2 58 (41.4)
3–4 39 (27.9)
5 or greater 26 (18.6)
No response 1 (0.7)
In the past 3 months, how frequently did you remember to take the double-dose 24 hours before your sexual encounter?a, N (%)
Never–Rarely 7 (5.7)
Sometimes 12 (9.8)
Often–Always 104 (84.6)
In the past 3 months, on average, how many hours before your sexual encounter did you take your double-dose?a, N (%)
0–1 9 (7.3)
2–5 76 (61.8)
6–10 16 (13.0)
11–15 6 (4.9)
16–20 5 (4.1)
21–24 11 (8.9)
In the past 3 months how frequently did you remember to take your single dose 24 hours after the double-dose?a, N (%)
Never–Rarely 1 (0.8)
Sometimes 7 (5.7)
Often–Always 113 (91.9)
No response 2 (1.6)
In the past 3 months how frequently did you remember to take your single dose 48 hours after the double-dose?a, N (%)
Never–Rarely 3 (2.4)
Sometimes 8 (6.5)
Often–Always 111 (90.2)
No response 1 (0.8)
How confident do you feel about the effectiveness of on-demand PrEP versus once-daily PrEP?, N (%)
2-1-1 PrEP is less effective than once-daily PrEP 18 (12.9)
2-1-1 PrEP is as effective as once-daily PrEP 102 (72.9)
2-1-1 PrEP is more effective compared to once-daily PrEP 2 (1.4)
No response 18 (12.9)
What are some strategies that have helped you remember your 2-1-1 doses?, N (%)
Use an alarm either on your cell phone or a clock 53 (37.9)
Take medication after a certain daily activity (such as brushing your teeth or eating breakfast) 40 (28.6)
Use pillbox (or medi-set) 28 (20.0)
Use an application on your cell phone 17 (12.1)
Writing a note to yourself 16 (11.4)
Other 13 (9.3)
Which of the following healthcare team members would you feel comfortable talking to about 2-1-1 PrEP?, N (%)
Provider (Physician, Nurse Practitioner, Physician Assistant) 110 (78.6)
PrEP Navigator 96 (68.6)
Nurse 92 (65.7)
Case Manager or Social Worker 64 (45.7)
Pharmacist 63 (45.0)
Peer Navigator 47 (33.6)
What barriers have you experienced with the 2-1-1 dosing strategy?, N (%)
Unplanned sexual encounters (i.e., missing the double dose 2–24 hours before a sexual encounter) 61 (43.6)
Trouble remembering the dosing schedule after the double dose (i.e., at 24 and 48 hours after the double dose) 41 (29.3)
Lack of healthcare provider knowledge about 2-1-1 dosing 33 (23.6)
Cost associated with prescription and lack of insurance coverage 22 (15.7)
Stigma 13 (9.3)
Alcohol/drug use or mental health challenges 8 (5.7)
Other 6 (4.3)
What challenges have you encountered related to your PrEP medication within the past month?b, N (%)
Lab tests 27 (25.5)
Refills 20 (18.9)
No appointments available 18 (17.0)
Communication with your medical provider 12 (11.3)
I haven’t experienced challenges 60 (56.6)
How has your city’s new Coronavirus policies affected how you seek out romantic or sexual partners?b, N (%)
Completely stopped sexual encounters 40 (37.7)
Exclusively meeting with previous or known partners 23 (21.7)
Having sex less frequently and with caution 18 (17.0)
Unaffected by policies 12 (11.3)
Sharing online content (messages, photos, and videos) 10 (9.4)
No response 3 (2.8)

aN = 123.

bN = 106 (during shelter-in-place due to the SARS-CoV-2 pandemic).