Table 7. Discriminatory ability of each prediction model for any type of incident fracture based on the C-index, Net Reclassification Improvement (NRI), and Integrated Discrimination Improvement (IDI).
Variables | C-index (95% CI) | P-value | NRI | P | IDI | P-value |
---|---|---|---|---|---|---|
Established risk factors | 0.784 (0.699–0.869) | Reference | Reference | Reference | ||
Established risk factors + serum Mg | 0.789 (0.705–0.873) | 0.49 | 0.174 | 0.16 | 0.001 | 0.31 |
Established risk factors + L2-L4 BMD | 0.825 (0.750–0.899) | 0.076 | 0.497 | 0.0028** | 0.039 | 0.012* |
Established risk factors + serum Mg + L2-L4 BMD | 0.830 (0.759–0.901) | 0.041* | 0.600 | 0.00044** | 0.041 | 0.010* |
Established risk factors include age, BMI, HD duration, past incident fracture, use of phosphate binders, total hip DXA BMD and 1//3 radius DXA BMD as covariates with P<0.05 in the univariate analysis.