Table 6. Univariate association with recurrence-free survival.

Variables		N	RFS
			HR (95%CI)	P-value	Log-rank P-value
Sex	Male	10	2.98 (0.50–56.65)	0.26	0.29
	Female	6	Ref.
Age	>65 years	7	1.21 (0.23–5.61)	0.81	0.81
	<65 years	9	Ref.
Stage	IV	3	11.43 (1.09–247.04)	0.04	0.01
	I–III	13	Ref.
Postoperative chemotherapy	Done	10	1.74 (0.38–12.22)	0.49	0.50
	None	6	Ref.
IHC	dMMR	8	0.69 (0.14–3.13)	0.62	0.62
	pMMR	8	Ref.
TMB	<10 mut/Mb	3	2.97 (0.41–15.37)	0.25	0.18
	≥10 mut/Mb	13	Ref.
SMAD4	Mutation	5	4.15 (0.90–21.41)	0.07	0.04
	Wild	11	Ref.

IHC: immunohistochemical, TMB: tumor mutational burden, mut/MB: mutations per megabase of DNA, MMR: mismatch repair, dMMR: deficient mismatch repair, pMMR: proficient mismatch repair, HR: hazard ratio, RFS: recurrence-free survival.