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. 2021 May 8;49(9):5095–5105. doi: 10.1093/nar/gkab299

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Mre11 hypomorphism alters DSB repair pathway utilization. (A) Schema depicting the role of Mre11-mediated end resection in the regulation of DSB repair pathway choice. (B) Mre11^ATLD1/ATLD1 MEFs exhibit reduced expression of the MRN complex by immunoblotting. (C–F) DSB repair products were identified in WT, Mre11^ATLD1-1 and Mre11^ATLD1-2 cells. (C) TMEJ-del 23 bp. (D) TMEJ-del 39 bp. (E) HR repair (HRD-500 donor) and (F) NHEJ-ins +1 bp. Mean ± SEM are shown. Statistical significance was assessed by two-tailed t-tests. * P < 0.05, ** P < 0.01, *** P < 0.001 and **** P < 0.0001.